W hat causes acromegaly?

Acromegaly is caused when a gland in your brain, called the pituitary gland, produces too much growth hormone over a period of time.1
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The over production of growth hormone is usually due to the presence of a non-cancerous (benign) tumour in the pituitary gland called an adenoma.1

In rare cases, acromegaly can be caused by a tumour in other parts of the body, such as the lungs, the pancreas or another part of the brain.1

Most tumours in the pituitary gland develop as a result of uncontrolled growth caused by a change in the DNA of a cell.2 However, it is not known exactly why this happens.2 Acromegaly occasionally runs in families, but generally it is not something that is inherited.1


  1. NHS England. Acromegaly. Available at: Last accessed September 2020.
  2. Moffitt cancer centre. What causes pituitary adenomas? Available at: Last accessed September 2020.